ASMs模型中异养菌减衰系数之间的关系及其测定

国际水协(IAWQ)推出的ASM1、ASM2、ASM2D号模型中描述微生物的衰亡过程采用了死亡-再生模式,而ASM3号模型中描述微生物的衰亡则采用了传统减衰模式,文章从两种减衰模式的机理出发,指出了两者之间的区别与联系,并详细推导了两种减衰模式中各参数之间的关系,以此得出了异养菌传统减衰系数bH'和死亡-再生减衰系数bH的测定计算方法。文中在20℃条件下,对以印染废水为主的实际污水处理厂活性污泥的异养菌减衰系数bH'和bH进行了测定,所得结果分别为0.20和0.50。     

Prenatal diagnosis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in a family with a previous fatal case of sudden unexpected death in childhood

Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is a potentially fatal inherited disease with a carrier frequency of approximately 1:100 in most Caucasian populations. The disease is implicated in sudden unexpected death in childhood. A prevalent disease-causing point mutation (A985G) in the MCAD gene has been characterized, thus rendering diagnosis easy in the majority of cases. Since the clinical spectrum of MCAD deficiency ranges from death in the first days of life to an asymptomatic life, there are probably other genetic factors—in addition to MCAD mutations—involved in the expression of the disease. Thus, families who have experienced the death of a child from MCAD deficiency might have an increased risk of a seriously affected subsequent child. In such a family we have therefore performed a prenatal diagnosis on a chorionic villus sample by a highly specific and sensitive polymerase chain reaction (PCR) assay for the G985 mutation. The analysis was positive and resulted in abortion. We verified the diagnosis by direct analysis on blood spots and other tissue material from the aborted fetus and from family members.     

Effects of mid-trimester induced abortion on the subsequent pregnancy

The outcome of the pregnancy following (a) a mid-trimester termination of pregnancy (TOP) for fetal neural tube defect (NTD) (77 women=group 1); (b) mid-trimester TOP for fetal Down's syndrome (13 women=group 2); (c) delivery of a baby with NTD (119 women=group 3) was studied. The prenatal fetal loss was relatively high in all groups. In group 1 it was similar to that found in other studies after first trimester TOP, in group 2 it was associated with advanced maternal age and the unexpected finding in group 3 was not attributable to advanced maternal age. It is suggested that a previous NTD per se might increase the risk of fetal loss in the next pregnancy. A previous mid-trimester TOP for NTD was not associated with an increase in premature labour, small for dates babies or congenital abnormality in the next pregnancy, but there was a slight increase in the number of babies weighing less than 2500 g.     

内蒙古癌死亡率与土壤环境中化学元素的关系

利用中国癌死亡率与土壤环境中化学元素的相关性研究成果，研究了内蒙古癌死亡率与土壤环境中化学元素：As、Cd、Co、Cu、Hg、Mn、Ni、Pb、Se、V、Li、Na、K、Rb、Cs、Mg、Ca、Sr、Ba、B、Al、Ga、In、Tl、Sc、Y、La、Ce、Pr、Nd、Tb、Dy、Ho、Er、Tm、Yb、Lu、Th、U、Sn、Ti、Zr、Hf、Sb、Bi、Ta、Te、Mo、W、Br、I、Fe等52个元素含量的关系。     

TNT当量法预测某石化设备爆炸后果评价

以烃化反应器为模拟发生泄漏事故源,泄漏的物料形成爆炸性气体,发生爆炸事故,采用TNT当量法预测爆炸事故后果,通过公式,计算出因爆炸冲击波导致肺出血而引起死亡的概率为0.5的半径.     

NO参与铝诱导蚕豆保卫细胞死亡的调控

铝(Al)是地壳中含量最丰富的金属元素,是酸性土壤中导致植物生长抑制和作物产量下降的一个主要因素,但铝毒性作用机制尚不清楚.本文以蚕豆叶表皮为材料,研究铝胁迫对气孔保卫细胞活性的影响,探讨NO在铝诱导细胞死亡中的作用.结果表明,一定浓度的A1Cl3可诱导气孔保卫细胞活性降低,部分细胞死亡,且随着铝浓度的增高细胞死亡率增高.死细胞呈现核固缩、核崩解、凋亡小体等典型凋亡特征,且凋亡抑制剂Z-Asp-CH2-DCB能阻止AlCl3诱发的细胞死亡.用NO清除剂c-PTIO、NO合酶抑制剂L-NAME或硝酸还原酶抑制剂NaN3降低铝处理组胞内NO后,细胞死亡率显著降低,胞内ROS、Ca2+水平同期降低;NaN3还能降低铝处理组中具有程序性死亡特征的细胞比率.用ROS清除剂AsA清除铝处理组胞内ROS后,细胞死亡率显著降低,胞内Ca2+和NO水平亦显著降低;铝处理液中加入Ca2+通道抑制剂LaCl3后,细胞死亡率低于铝单独处理组,胞内ROS和NO水平无明显改变.研究结果表明,铝胁迫引起的胞内NO合成增加通过Ca2+信号途径介导了保卫细胞的程序性死亡.     

区域性煤矿百万吨死亡率指标的宏观预测研究

为了对煤矿安全状况进行宏观预测,提出区域性煤矿安全状况评价指标体系并建立了以煤矿百万吨死亡率指标标征区域性煤矿安全状况的灰色预测模型。在对煤矿综合机械化采煤率、大型煤矿产量比例、原煤全员效率指标预测分析的基础上,利用多元回归法综合预测煤矿百万吨死亡率指标。实例计算证明:建立的预测模型具有输入数据少、建模简单、计算快捷等优点;客观地反映出区域性的煤矿安全状况;该模型可进行煤矿安全的短期预测,并为制定煤矿安全控制指标提供理论依据。     

Mercuric chloride effects on adult rat oval cells-induced apoptosis

In the present investigation, the toxicity of mercuric chloride (HgCl₂) was evaluated in adult oval cells isolated from rat utilizing the 2-acetylaminofluorene/partial hepatectomy technique. Isolated oval cells were incubated with 5 μM of HgCl₂ for 8 hr to elucidate in vitro cytotoxic responses. Recently, autophagic cell death was found in rat hepatocytes in vitro within 30 min of incubation with 5 μM of mercury (Hg) which triggered apoptosis and necroptosis in a time-dependent manner. Nuclear degradation occurred within 30 min of incubation and progressed with time until 8 hr. Apoptosis evidenced by activation of caspase-dependent pathway between 30 min to 8 hr of incubation was mediated via interchange of death domain signaling pathways. Receptor-interacting protein played a positive role to modulate the death domain receptors in the scenario of apoptotic death of oval cells until 6 hr. Autophagic marker proteins ATG12 and LC3B exerted a significant role in triggering apoptosis in 5 μM Hg-treated oval cells. No apparent expression of apoptosis-inducing-factor (AIF) and HMGB1 indicated absence of caspase-independent apoptosis and necrosis in the rat oval cells between 30 min and 8 hr. Thus a low concentration of Hg modulates programmed cell death in adult rat oval cells by altering expression of proteins involved in the molecular mechanisms of cellular functions.     

Effect on fatality risk of changing from secondary to primary seat belt enforcement

BACKGROUND: Most seat belt use laws originally passed in the United States contained language restricting enforcement to drivers already stopped for some other reason. States that have since removed this secondary enforcement restriction have reported increased seat belt use. The purpose of the present study was to estimate the effect of these law changes on driver fatality rates. METHOD: Trends in passenger vehicle driver death rates per billion miles traveled were compared for 10 states that changed from secondary to primary seat belt enforcement and 14 states that remained with secondary enforcement. RESULTS: After accounting for possible economic effects and other general time trends, the change from secondary to primary enforcement was found to reduce annual passenger vehicle driver death rates by an estimated 7% (95% confidence limits 3.0-10.9). CONCLUSION: The majority of U.S. states still have secondary enforcement laws. If these remaining secondary laws were amended, an estimated 696 deaths per year could be prevented.